Variability in Insulin Action: Mechanisms, Implications, and Recent Advances

An important drawback of conventional human insulin formulations is their variable absorption and unpredictable insulin activity. Modern insulin analogs offer several clinical advantages over conventional human insulin therapies, including a more predictable and physiologically accurate profile of insulin absorption and action. Accumulating evidence suggests that insulin therapies exhibiting less within-patient variability are associated with greater convenience, a reduced risk of hypoglycemia, and in some cases, reduced weight gain.