Controversy resolved! A combination of gas-phase ion-molecule reactions and theoretical studies confirm bisligated mononuclear Au(I) complexes are unable to undergo oxidative addition of iodobenzene for Sonogashira coupling, but that the ligated gold clusters [Au(3)L(n)](+) (L=Ph(2)P(CH(2))(n)PPh(2); n=3-6) activate the C-I bond. DFT calculations on the transition states show that the linker size n tunes the cluster reactivity.
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Robinson et al. (2012) studied this question.
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