Key result
Type 2 diabetes mellitus was associated with a shift in EEG power to lower frequencies, increased P300 latency, and decreased P300 and N100 amplitudes compared to healthy controls.
Why the study?
This systematic review was conducted to examine the functional brain changes underlying cognitive dysfunctions in patients with T2DM using electroencephalogram.
What are the functional brain changes underlying cognitive dysfunctions in T2DM patients as measured by EEG and ERP?
Systematic Review (n=16)
What are the functional brain changes underlying cognitive dysfunctions in T2DM patients as measured by EEG and ERP?
T2DM is associated with measurable changes in brain electrical activity (EEG/ERP) indicative of cognitive dysfunction, placing it on a continuum toward dementia.
EEG/ERP changes may mark cognitive dysfunction in T2DM; extends diabetes-dementia continuum evidence but needs prospective validation.
Introduction: Electroencephalogram (EEG) has the potentials to decipher the neural underpinnings of cognitive processes in clinical and healthy populations. Objective: The current systematic review is intended to examine the functional brain changes underlying cognitive dysfunctions in T2DM patients. Methods: The review was conducted on studies published in the PubMed, WebofScience, Cochrane, PsycInfo database till June 2021. The keywords used were electroencephalogram, T2DM, cognitive impairment/dysfunction. We considered studies using resting-state EEG and ERP. The preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines were followed to compile the studies. Results: The search yielded a total of 2384 studies. Finally, 16 independent studies were included. There was a pattern of a shift in EEG power observed from higher to lower frequencies in T2DM patients, though to a lesser degree than Alzheimer's disease patients. P300 latency was increased in T2DM patients mainly over frontal, parietal, and posterior regions. P300 and N100 amplitudes were decreased in T2DM patients than in healthy controls. Conclusion: The results indicate that T2DM has consequences for cognitive functions, and it finds a place in the continuum of healthy cognition to dementia.
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Kanthi et al. (2022) conducted a systematic review in Type 2 Diabetes Mellitus (n=16). Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Functional brain changes (EEG power, P300 latency, P300 and N100 amplitudes). Type 2 diabetes mellitus was associated with a shift in EEG power to lower frequencies, increased P300 latency, and decreased P300 and N100 amplitudes compared to healthy controls.
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