Demonstrating a Novel Experience with Human Periodontium-Derived Stem Cells: A Review

Unlike muscle cells, blood cells, or nerve cells-which do not normally replicate themselves-stem cells may replicate many times by a process called proliferation.A starting population of stem cells that proliferates for many months in the laboratory can yield to millions of cells.If the resulting cells continue to be unspecialized, like the parent stem cells, the cells are meant to be capable of long-term self-renewal.Properties of stem cells can be illustrated in vitro, using methods such as clonogenic assays, where single cells are characterized by their ability to differentiate and self-renew [2,3].As well, stem cells can be isolated based on a distinctive set of cell surface markers.However, in vitro culture conditions can alter the behavior of cells, making it unclear whether the cells will behave in a similar manner in vivo.Considerable debate exists whether some proposed adult cell populations are truly stem cells.