What is the clinical evidence from this study?

Study design: Other. Population: Angiotensin II-induced myocyte necrosis. Intervention: Losartan vs. Angiotensin II alone. Primary outcome: Myocyte necrosis.

What does this research mean for the field?

Angiotensin II-induced cardiac myocyte necrosis is mediated through the AT1 receptor and is prevented by AT1 receptor antagonism with losartan. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1994Journal of Cardiovascular Pharmacology

Angiotensin II (AII)-Induced Myocyte Necrosis: Role of the AII Receptor

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Key result

Losartan prevents angiotensin II-induced myocyte necrosis in rats, demonstrating cardiotoxicity is receptor-mediated.

Why the study?

Does losartan prevent angiotensin II-induced myocyte necrosis in rats?

Population

Rats (7 groups, 4-6 rats/group)

Comparison

Losartan given 2 days before and throughout… vs Angiotensin II (150 ng/min) infusion alone

Design

Preclinical

Follow-up

Up to 9 days of infusion or 7 days post-infusion

Authors

AKAmeer KabourMercy St. Vincent Medical Center JHJeffrey R. HenegarUniversity of Missouri JJJoseph S. JanickiHeart Failure & Transplant

Discussion

Member takes

Implication

AT1-mediated angiotensin II cardiotoxicity in rats; leaves open translation to human heart failure or therapy.

Structured PICO

Does losartan prevent angiotensin II-induced myocyte necrosis in rats?

Population

Rats divided into 7 groups of 4-6 animals each, receiving angiotensin II infusions with or without the AT1 antagonist losartan for up to 9 days.

Intervention

Losartan (7.5 mg/day) given 2 days before and throughout angiotensin II (150 ng/min) infusion

Comparator

Angiotensin II (150 ng/min) infusion alone

Outcome

Myocyte necrosis and injurysurrogate

Angiotensin II-induced myocyte necrosis is mediated by the AT1 receptor and can be prevented by AT1 antagonism with losartan.

Cite This Study

Kabour et al. (1994) studied Angiotensin II-induced myocyte necrosis. Losartan vs. Angiotensin II alone was evaluated on Myocyte necrosis. Co-administration of the AT1 antagonist losartan prevented angiotensin II-induced myocyte necrosis in rats, demonstrating that AII-related cardiotoxicity is receptor mediated.

synapsesocial.com/papers/6aa60ef0014c9b816df4ddd3 https://doi.org/10.1097/00005344-199404000-00005

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Angiotensin II (AII)-Induced Myocyte Necrosis: Role of the AII Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II (AII)-Induced Myocyte Necrosis: Role of the AII Receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider