Key result
Elevated blood pressure in rats blunts aortic responses to acetylcholine and histamine.
Population
Aortae from spontaneously hypertensive rats, low blood pressure SHR, left renal artery stenosed LBP-SHR, and…
Comparison
Administration of noradrenaline, acetylcholine… vs Aortae from normotensive Wistar-Kyoto rats (WKY)
Design
Preclinical
Authors
Loading...
Should not change hypertension management; leaves open translation of rat aortic hyporesponsiveness to humans.
Hypertension in rat models is associated with decreased aortic responsiveness to acetylcholine and histamine, involving both endothelium-dependent and independent mechanisms.
Sim et al. (1987) studied Hypertension. Hypertension vs. Normotensive Wistar-Kyoto rats (WKY) was evaluated on Responsiveness of aortae to acetylcholine, histamine and noradrenaline. Elevation of blood pressure above normal in rats results in a decreased response of the aortae to acetylcholine and histamine in both endothelium-mediated relaxation and nonendothelium-mediated contraction.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: