The organocatalytic asymmetric Michael addition of 2,2‐dimethyl‐1,3‐dioxan‐5‐one (1) was performed with various nitro alkenes 2 using a number of proline‐based catalysts (A–M) affording polyfunctional nitro ketones 3. Reverse diastereoselectivity was observed with the diphenylprolinol catalyst J, and the best diastereo‐ and enantiomeric excesses were achieved with the sulfonamide catalyst M (de = 84–98 %, ee = 81–86 %). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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Enders et al. (2006) studied this question.
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