The lateral aspect of the left hind limb of 70 New Zealand white rabbits was irradiated under general anesthesia. The rabbits were divided into three groups: (a) control, (b) 1,000 rads, and (c) 3,000 rads. V2 cancer was infused into the afferent lymphatic of the popliteal lymph node of the animals. In controls the node acted as a barrier to tumor spread for up to three weeks. Ionizing irradiation significantly increased distant tumor growth in the animals.
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O’Brien et al. (1970) studied this question.
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