Use of Dexmedetomidine and Ketamine for Rapid Opioids Detoxification in General Anesthesia

Deliverance from opioids dependency is challenging subjects and there are varieties of methods. There are new approaches base on anesthesia techniques for rapid opioids’ detoxification and recently, these methods are increasingly popular. These methods aimed at reducing the time of opioid detoxification and decreasing intensity of opioids withdrawal. Our protocol for opiate detoxification under general anesthesia by using Propofol, Dexmedetomidine plus ketamine while patients receive Naloxone represents a potentially effective treatment, and it could constitute as a safe method. We found less hemodynamic changes, withdrawal signs like involuntary movement, muscle twitch, lacrimation and sweating comparison with a combination of Propofol, Midazolam, and Atracurium. We believe that a well- designed protocol will accelerate detoxification and attenuate withdrawal symptoms.