What is the clinical evidence from this study?

Study design: Other. Population: Ischemia-reperfusion (I/R) injury. Intervention: BK(Ca) channel opener NS-1619 vs. Control / antagonists (MnTBAP or paxilline). Primary outcome: Left ventricular pressure and infarct size (2.5-fold increase in developed LVP and 2.5-fold decrease in infarct size).

What does this research mean for the field?

Pharmacological opening of big conductance Ca2+-sensitive K+ channels with NS-1619 protects against myocardial ischemia-reperfusion injury via superoxide radical-dependent mitochondrial preconditioning. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 26, 2005AJP Heart and Circulatory Physiology

Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation

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Key result

NS-1619 improves LVP and reduces infarct size ~2.5-fold in isolated guinea pig hearts.

2.5-fold increase in developed LVP and 2.5-fold decrease in infarct size

Population

Isolated guinea pig hearts

Comparison

BK channel opener NS-1619 given for 15 min… vs Control or NS-1619 combined with MnTBAP or…

Design

Preclinical

Authors

DSDavid F. StoweCross-Cutting Cardiology MAMohammed AldakkakMedical College of Wisconsin ACAmadou K.S. CamaraMedical College of Wisconsin

Discussion

Member takes

Implication

BK(Ca) channel opening is hypothesis-generating for cardioprotection in preclinical models; should not yet influence clinical practice.

Structured PICO

Population

Isolated guinea pig hearts subjected to global ischemia-reperfusion.

Intervention

BK(Ca) channel opener NS-1619 given for 15 min, ending 25 min before 30 min of global ischemia-reperfusion

Comparator

Control (no NS-1619) or NS-1619 combined with MnTBAP (TB) or paxilline (PX)

Outcome

Left ventricular pressure (LVP) and infarct sizesurrogate

Main Result

Effect estimate: 2.5-fold increase in developed LVP and 2.5-fold decrease in infarct size

Pharmacological opening of the BK(Ca) channel induces mitochondrial preconditioning and protects against ischemia-reperfusion injury via a ROS-dependent mechanism.

Cite This Study

Stowe et al. (2005) studied Ischemia-reperfusion (I/R) injury. BK(Ca) channel opener NS-1619 vs. Control / antagonists (MnTBAP or paxilline) was evaluated on Left ventricular pressure and infarct size (2.5-fold increase in developed LVP and 2.5-fold decrease in infarct size). Pretreatment with the BK(Ca) channel opener NS-1619 resulted in a 2.5-fold increase in developed left ventricular pressure and a 2.5-fold decrease in infarct size in isolated guinea pig hearts.

synapsesocial.com/papers/6aa61e96fff38ca398dd4625 https://doi.org/10.1152/ajpheart.00763.2005

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Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider