Key result
Elevated NT-proBNP identifies pediatric CHD with ~90% sensitivity.
Why the study?
The study evaluated the value of plasma NT-ProBNP concentration in diagnosing congenital heart disease in children.
Does plasma NT-ProBNP concentration have diagnostic value for congenital heart disease in children?
Cross-Sectional (n=160)
No
Does plasma NT-ProBNP concentration have diagnostic value for congenital heart disease in children?
Effect estimate: AUC 0.735
p-value: p=<0.05
Plasma NT-ProBNP is a useful biomarker for diagnosing congenital heart disease in children and correlates with disease severity, including heart failure and pulmonary hypertension.
May support NT-ProBNP as a biomarker for congenital heart disease in children; leaves open validation in larger prospective studies.
Objective: Research the value of plasma NT-ProBNP concentration in diagnosing congenital heart disease in children. Objects and methods of study: Controlled study on 80 children with congenital heart disease at the Vietnam National Children's Hospital from April 2018 to August 2019. Results: NT-ProBNP concentrations in all types of congenital heart disease were higher than in the control group (p<0.05). NT-ProBNP concentration was highest in the left-right shunt group and lowest in the cyanotic congenital heart disease group with a statistically significant difference (p>0.05). NT-ProBNP concentration was highest in the severe heart failure group, followed by the moderate, mild and no heart failure groups and were all higher than the control group (p < 0.01). NT-ProBNP concentration was the highest in the severe pulmonary hypertension group, followed by the moderate, mild, and no pulmonary hypertension groups and were all higher than the control group (p<0.05). The optimal cutoff point of NT-ProBNP is 671 pg/ml, which is valuable for diagnosing congenital heart disease with a sensitivity of 90.2%, a specificity of 53.1% and an area under the curve of 0.735. Conclusion: NT-ProBNP levels are increased in congenital heart disease in children. Increased NT-ProBNP concentrations are associated with left-right shunting, degree of heart failure and pulmonary hypertension.
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Anh Ngo (2023) conducted a cross-sectional in Congenital heart disease (n=160). Plasma NT-ProBNP concentration vs. Healthy controls was evaluated on Diagnosis of congenital heart disease (AUC 0.735, p=<0.05). Plasma NT-ProBNP concentrations were significantly higher in children with congenital heart disease compared to controls, with an optimal cutoff of 671 pg/ml yielding 90.2% sensitivity and 53.1% specificity (AUC 0.735).
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