Key result
Sequential deletion of multiple genes from the African swine fever virus genome using the cre/loxP recombination system did not significantly alter virus replication.
The cre/loxP recombination system can be used to sequentially delete multiple genes from the ASFV genome without significantly altering virus replication.
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Cre/loxP enables sequential multi-gene ASFV deletions without replication changes; leaves open in vivo attenuation and vaccine potential.
Abrams et al. (2012) studied this question. Sequential deletion of multiple genes from the African swine fever virus genome using the cre/loxP recombination system did not significantly alter virus replication.
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