Key result
Atomic bomb radiation at 1 Gy is linked to ~30% greater risk of aortic arch calcification.
Why the study?
Does atomic bomb radiation exposure increase the prevalence of asymptomatic atherosclerosis in survivors?
Cross-Sectional (n=1,804)
Does atomic bomb radiation exposure increase the prevalence of asymptomatic atherosclerosis in survivors?
Odds Ratio: 1.3 (95% CI 1.05–1.53)
p-value: p=<0.05
Atomic bomb radiation exposure is associated with an increased prevalence of aortic arch calcification, but not carotid artery atherosclerosis, in survivors.
Supports radiation as a vascular risk factor in survivors; leaves open causality, generalizability, and clinical event links.
PURPOSE: To determine whether exposure to atomic bomb radiation altered the prevalence of asymptomatic atherosclerosis. MATERIAL AND METHODS: In a cross-sectional analysis, we examined aortic arch calcification by plain chest radiography and common carotid artery intima-media thickness (IMT) by ultrasonography among 1804 survivors of the atomic bombing in Hiroshima. We evaluated the association between atherosclerotic changes and radiation exposure, while adjusting for potentially confounding factors. RESULTS: Multivariate logistic regression analysis showed that aortic arch calcification was significantly associated with radiation exposure (p < 0.05). The odds ratio at 1 Gy was 1.30 (95% confidence interval [CI]: 1.05 - 1.53) for men and 1.31 (95% CI: 1.13 - 1.51) for women. Carotid artery IMT did not vary significantly with radiation dose (p = 0.18). CONCLUSION: Radiation dose contributed to the prevalence of aortic atherosclerosis but not carotid artery atherosclerosis in atomic bomb survivors.
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Yamada et al. (2005) conducted a cross-sectional in asymptomatic atherosclerosis (n=1,804). Atomic bomb radiation exposure vs. Lower or no radiation exposure was evaluated on aortic arch calcification (OR 1.30, 95% CI 1.05-1.53, p=<0.05). Atomic bomb radiation exposure at 1 Gy was significantly associated with aortic arch calcification in men (OR 1.30; 95% CI 1.05-1.53) and women (OR 1.31; 95% CI 1.13-1.51).
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