Key result
Linkage analysis indicates the dystrophin-homologue sequence is not responsible for LGMD.
Why the study?
Is the dystrophin-homologous sequence on chromosome 6q linked to the gene responsible for autosomal recessive limb-girdle muscular dystrophy?
Population
226 individuals from 19 large unrelated Brazilian families with autosomal recessive limb-girdle muscular…
Design
Other
Authors
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Excludes dystrophin-homologue on 6q as LGMD cause; leaves open mapping of the responsible locus in recessive disease.
Observational (n=226)
Is the dystrophin-homologous sequence on chromosome 6q linked to the gene responsible for autosomal recessive limb-girdle muscular dystrophy?
The dystrophin-homologue sequence on chromosome 6q is not the gene responsible for autosomal recessive limb-girdle muscular dystrophy.
Passos‐Bueno et al. (1991) conducted an observational in Autosomal recessive limb-girdle muscular dystrophy (LGMD) (n=226). 6q probes flanking the dystrophin-homologous sequence was evaluated on Linkage with MYB (6q22-23), ESR (6q24-q27), and TCP1 (6q25-q27). Linkage analysis excluded linkage of the LGMD gene with MYB and ESR at θ = 0.10 and with TCP1 at θ = 0.05, indicating the dystrophin-homologue sequence is not responsible for LGMD.
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