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A series of new 2-Aryl-2,3-dihydro-1H-perimidine, derivatives (3a - j) were synthesized under reflux and at room temperature by condensation reaction of 1,8-diaminonaphthalene (2) with various substituted benzaldehyde using glacial acetic acid a catalyst. The synthesized compounds were characterized by spectroscopic methods, infrared (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR) and carbon nuclear magnetic resonance-distortionless enhancement by polarization (13C-NMR-DEPT). The synthesized compounds were screened for their biological activity against the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Escherichia coli. The results showed that 89% of the synthesized compounds were not active against S. aureus, while E. coli showed 100% sensitivity to the mentioned compound. These results illustrate the marked bactericidal effect of all the synthesized compounds.
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Salih et al. (2014) studied this question.
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