Key result
Aortic stenosis affects almost 8% of people ≥75 years of age and carries an annual cardiac death rate of 25% once symptoms develop unless aortic valve replacement is performed.
Why the study?
Do statins affect the progression or outcomes of aortic stenosis?
Do statins affect the progression or outcomes of aortic stenosis?
This text provides a general overview of the pathophysiology and natural history of aortic stenosis, setting the stage for a discussion on the potential role of statins.
A ortic stenosis (AS) is a relatively common cause of cardiac debility and death, increasing in frequency and severity with age; indeed, AS of at least moderate severity may affect almost 8% of people Ն75 years of age. 1 The natural history of AS is dependent on the myocardial response to the abnormal left ventricular pressure load caused by the stenotic valve, involving cardiomyocyte hypertrophy, hyperproduction of extracellular matrix collagen by cardiac fibroblasts, and other alterations in myocardial biology.When these changes become critically severe, symptoms develop (angina pectoris, syncope, exertional dyspnea, and other manifestations of pulmonary vascular congestion) followed predictably by cardiac death at an annual rate of 25% unless aortic valve replacement surgery is performed.
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Jeffrey Borer (2005) conducted an editorial in Aortic stenosis. Statins was evaluated. Aortic stenosis affects almost 8% of people ≥75 years of age and carries an annual cardiac death rate of 25% once symptoms develop unless aortic valve replacement is performed.
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