Key result
VA-ECMO and prone ventilation successfully treat severe respiratory and circulatory failure from metoprolol and amlodipine poisoning.
Case Report (n=1)
VA-ECMO combined with prone ventilation can be an effective rescue strategy for severe cardiogenic shock and respiratory failure secondary to massive beta-blocker and calcium channel blocker overdose.
May support VA-ECMO plus prone ventilation in refractory overdose shock; hypothesis-generating, requires prospective validation.
Extracorporeal life support (ECLS) represents the ultimate intervention for respiratory and circulatory failure. By maintaining hemodynamic stability, ECLS facilitates drug metabolism and organ recovery, thereby improving survival outcomes. We report a case of severe respiratory and circulatory failure resulting from the oral ingestion of 35 extended-release metoprolol tablets (25 mg each) and 100 extended-release amlodipine tablets (5 mg each). The patient responded favorably to venoarterial extracorporeal membrane oxygenation (VA-ECMO) combined with prone-position ventilation.
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Zhao et al. (2025) conducted a case report in Severe respiratory and circulatory failure resulting from high-dose metoprolol and amlodipine poisoning (n=1). Venoarterial extracorporeal membrane oxygenation (VA-ECMO) combined with prone-position ventilation was evaluated on Clinical response. Venoarterial extracorporeal membrane oxygenation combined with prone-position ventilation successfully treated a patient with severe respiratory and circulatory failure from metoprolol and amlodipine poisoning.
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