Key result
Specific GPIb alpha polymorphisms linked to shorter collagen-adrenaline-induced closure times versus reference genotypes.
Why the study?
Do glycoprotein Ib alpha polymorphisms influence platelet plug formation under high shear rates in healthy individuals?
Observational (n=233)
Do glycoprotein Ib alpha polymorphisms influence platelet plug formation under high shear rates in healthy individuals?
Specific glycoprotein Ib alpha polymorphisms (C/D VNTR allele and (-5)T/T Kozak genotype) are associated with faster platelet plug formation under high shear rates, providing a potential functional mechanism for their association with arterial thrombosis.
Supports GPIbα variant effects on platelet reactivity; hypothesis-generating for thrombosis risk without practice change.
Platelet polymorphisms (Kozak, VNTR and HPA-2) within glycoprotein (GP)Ib alpha may be associated with an increased risk of arterial thrombosis. However, the functional role of these polymorphisms has not been clarified. Their influence on platelet plug formation under high shear rates was, therefore, examined in 233 healthy individuals. Collagen-adrenaline-induced closure time was shorter in carriers of the C/D versus C/C VNTR allele and in homozygotes with the (-5)T/T versus (-5)C/T Kozak genotype as determined by novel polymerase chain reaction methods. The HPA-2 genotype had no effects, and the density of GPIb alpha molecules was not influenced by GPIb alpha genotypes.
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Jilma‐Stohlawetz et al. (2003) conducted an observational in Healthy (n=233). Glycoprotein Ib alpha polymorphisms (Kozak, VNTR and HPA-2) vs. Reference genotypes (C/C VNTR, (-5)C/T Kozak) was evaluated on Collagen-adrenaline-induced closure time. Glycoprotein Ib alpha polymorphisms (C/D VNTR allele and (-5)T/T Kozak genotype) were associated with shorter collagen-adrenaline-induced closure times compared to reference genotypes.
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