Key result
Platelet membrane glycoprotein polymorphisms of GPIbalpha and GPIa significantly influenced ex vivo thrombus formation in a shear rate-dependent manner.
Why the study?
Do platelet membrane glycoprotein polymorphisms affect experimental arterial thrombus formation in healthy men?
Population
40 healthy male volunteers
Comparison
Presence of platelet membrane glycoprotein… vs Different genotypes of the specified platelet…
Design
Cross-sectional
Authors
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These polymorphisms were associated with shear-dependent ex vivo thrombus formation; hypothesis-generating for arterial thrombosis risk but should not change practice.
Observational (n=40)
Do platelet membrane glycoprotein polymorphisms affect experimental arterial thrombus formation in healthy men?
Genetic variations in GPIbalpha and GPIa receptors significantly influence platelet thrombus formation in a shear rate-dependent manner.
Cadroy et al. (2001) conducted an observational in Healthy (n=40). Platelet membrane glycoprotein polymorphisms was evaluated on Platelet thrombus formation ex vivo. Platelet membrane glycoprotein polymorphisms of GPIbalpha and GPIa significantly influenced ex vivo thrombus formation in a shear rate-dependent manner.
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