Key result
Treatment with ACTH and B6 vitamin significantly increased time domain parameters of heart rate variability in 19 patients with infantile spasm, diminishing autonomic dysfunction.
Why the study?
Does adrenocorticotropic hormone (ACTH) and vitamin B6 administration improve heart rate variability in patients with infantile spasm?
Observational (n=32)
Does adrenocorticotropic hormone (ACTH) and vitamin B6 administration improve heart rate variability in patients with infantile spasm?
Treatment with ACTH and vitamin B6 improves cardiac autonomic dysfunction, as measured by heart rate variability, in patients with infantile spasm.
Answers are grounded in this paper and cite their sources.
May support autonomic benefits of ACTH in infantile spasms; leaves open need for randomized confirmation of clinical outcomes.
Infantile spasm is an age-dependent epileptic-encephalopathy syndrome. Cardiac autonomic function is frequently altered in epilepsy. In this study, we examined heart rate variability in patients with infantile spasm before and after treatment. Nineteen patients with infantile spasm and 13 healthy comparisons were enrolled in the study. Cardiac rhythm was recorded with a Holter device for 24 hours before adrenocorticotropic hormone (ACTH) (Synacthen depot) and B6 vitamin administration and 1 month after treatment. Heart rate variability analysis found lower heart rate variability parameters in patients with infantile spasm at the onset of the syndrome, prior to treatment with ACTH. The time domain parameters of heart rate variability values showed a statistically significant increase following ACTH treatment. Our data suggest that patients with infantile spasm exhibit lower heart rate variability parameters, and the treatment of spasms with ACTH and B6 together diminished the autonomic dysfunction in our cohort.
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Gençpınar et al. (2015) conducted an observational in Infantile spasm (n=32). Adrenocorticotropic hormone (ACTH) and B6 vitamin vs. Pre-treatment baseline and healthy comparisons was evaluated on Heart rate variability (time domain parameters). Treatment with ACTH and B6 vitamin significantly increased time domain parameters of heart rate variability in 19 patients with infantile spasm, diminishing autonomic dysfunction.
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