Key result
Dravet syndrome is linked to depressed HRV versus other epilepsies independent of antiepileptic therapy.
Why the study?
Do patients with Dravet syndrome present abnormalities in electrical and autonomic cardiac function compared to healthy children and patients with other epileptic syndromes?
Population
20 patients affected by Dravet syndrome (DS), mean age 6.8 ± 4 years, 11 female.
Design
Case-control
Authors
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May heighten SUDEP vigilance in DS; leaves open whether HRV assessment refines risk stratification in refractory epilepsy.
Case-Control (n=80)
Do patients with Dravet syndrome present abnormalities in electrical and autonomic cardiac function compared to healthy children and patients with other epileptic syndromes?
Patients with Dravet syndrome exhibit depressed heart rate variability and increased adrenergic tone compared to controls, which may contribute to their high risk of sudden unexpected death in epilepsy.
Delogu et al. (2011) conducted a case-control in Dravet syndrome (n=80). Dravet syndrome vs. Other epileptic syndromes (with and without antiepileptic drugs) and healthy children was evaluated on Ventricular repolarization and heart rate variability (HRV). Dravet syndrome was associated with depressed heart rate variability compared to healthy children and patients with other forms of epilepsy, independent of antiepileptic therapy.
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