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June 28, 2003Critical CareOpen Access

Science Review: Vasopressin and the cardiovascular system part 2 - clinical physiology.

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Key result

Vasopressin shows promise for vasodilatory shock but routine clinical use awaits randomized trials.

Why the study?

Does vasopressin improve outcomes such as organ failure and mortality in patients with vasodilatory shock?

Population

Patients with vasodilatory shock states

Design

Review

Authors

CHCheryl L. HolmesUniversity of British ColumbiaDLDonald W. LandryLeibniz University HannoverJGJohn GrantonHeart Failure & Transplant

Discussion

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Implication

Caution against routine vasopressin use in vasodilatory shock; leaves open its impact on mortality and organ failure pending RCTs.

Structured PICO

Does vasopressin improve outcomes such as organ failure and mortality in patients with vasodilatory shock?

P
Population
Patients with vasodilatory shock states
I
Intervention
Vasopressin

While vasopressin is an emerging therapy for vasodilatory shock, its routine clinical use should await randomized controlled trials evaluating hard outcomes like mortality and organ failure.

Limitations

  • Clinical studies to date have been relatively small and focused on physiologic outcomes
  • Potential adverse effects of vasopressin

Cite This Study

Holmes et al. (2003) conducted a review in Vasodilatory shock states. Vasopressin was evaluated. Vasopressin is emerging as a therapy for vasodilatory shock, but routine clinical use should await randomized controlled trials evaluating its effect on organ failure and mortality.

synapsesocial.com/papers/6aa63431bc2c7db7488e57d3https://doi.org/10.1186/cc2338
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute Hemodynamic Effects of Conivaptan, a Dual V <sub>1A</sub> and V <sub>2</sub> Vasopressin Receptor Antagonist, in Patients With Advanced Heart Failure2001 · 363 citations
  2. 2Intravenous Arginine-Vasopressin in Children With Vasodilatory Shock After Cardiac Surgery1999 · 241 citations
  3. 3Adenoviral Gene Transfer of the Human V2 Vasopressin Receptor Improves Contractile Force of Rat Cardiomyocytes1999 · 28 citations
  4. 4Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart1997 · 269 citations
  5. 5Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock1997 · 999 citations