We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
No takes yet. Share an insight, caveat, or question.
Babron et al. (1993) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: