Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Nıhat Yumuşak; Murat Sadıç; Gözde Yücel; Hasan İkbal Atılgan; Gökhan Koca; Meliha Korkmaz

doi:10.1097/mnm.0000000000000788

December 19, 2017Nuclear Medicine Communications

Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

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Key Points

To evaluate apoptosis and cell proliferation patterns during short-term and long-term kidney damage following radioiodine-131 exposure.
Allocated rats into three groups (n=10 per group): untreated controls (group 1), single oral radioiodine (111 MBq) with sacrifice at 7 days (group 2), and single oral radioiodine (111 MBq) with sacrifice at 10 weeks (group 3).
Excised kidneys and performed immunohistochemical analyses for the Na+/I- symporter, proliferation markers (PCNA, Ki-67), and apoptotic markers (caspase-3, caspase-8, caspase-9, and TUNEL assay).
Accumulation of Na+/I- symporter protein in kidney tissue was significantly greater at day 7 (group 2) than at 10 weeks (group 3, P<0.05).
Cell proliferation and apoptosis emerged by day 7 and peaked at week 10, with PCNA, Ki-67, caspase-3, caspase-8, caspase-9, and TUNEL values all significantly higher in group 3 than in the other groups (P<0.05).

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Implication

Animal study demonstrates progressive apoptosis and cell proliferation in rat kidneys after radioiodine-131 exposure, indicating delayed radiation nephrotoxicity.

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Yumuşak et al. (2017) studied this question.

synapsesocial.com/papers/6aa63687d3d41ccc68922e04 https://doi.org/10.1097/mnm.0000000000000788

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Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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