Key result
Novel modular 3,5-diaminopiperidine (DAP) ligands successfully bind to a conformational target in the internal ribosome entry site RNA of the hepatitis C virus.
Describes the synthesis of novel DAP ligands targeting the hepatitis C virus internal ribosome entry site RNA.
DAPper ligands: The 3,5-diaminopiperidine (DAP) heterocycle has been developed as a structural mimetic of the RNA-recognizing pharmacophore of the 2-DOS scaffold. Here we describe the synthesis of novel modular DAP ligands that bind to a conformational target in the internal ribosome entry site RNA of the hepatitis C virus.
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Carnevali et al. (2010) studied this question. Novel modular 3,5-diaminopiperidine (DAP) ligands successfully bind to a conformational target in the internal ribosome entry site RNA of the hepatitis C virus.
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