Key result
RNA aptamers targeting domain II of HCV IRES successfully bind and inhibit IRES-dependent translation.
Why the study?
The function of domain II of the hepatitis C virus internal ribosome entry site (IRES) and its potential as a target for RNA aptamers was investigated.
RNA aptamers targeting domain II of the HCV IRES can successfully bind to its apical loop and inhibit viral translation, presenting a potential therapeutic strategy.
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May support aptamer-based HCV antivirals; hypothesis-generating and leaves open clinical translation.
Koji Kikuchi (2003) studied Hepatitis C Virus (HCV). RNA aptamers targeted to domain II of HCV IRES was evaluated on Binding affinity and IRES-dependent translation inhibition. RNA aptamers with a consensus sequence complementary to the apical loop of domain II of HCV IRES successfully bound to the target and inhibited IRES-dependent translation.
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