Key result
MIAT rs1061540 T/T is linked to worse CAD severity and MALAT1 rs3200401 T/C to milder disease.
Why the study?
Long non-coding RNAs have emerged as biomolecules with diagnostic and prognostic utility in coronary artery disease, but the association of angiogenesis-related lncRNA variants with CAD susceptibility or severity had not been evaluated.
Are angiogenesis-related lncRNA variants associated with CAD susceptibility and severity in patients undergoing angiography?
Population
100 unrelated patients with stable CAD undergoing diagnostic coronary angiography and 100 controls
Comparison
Five angiogenesis-related lncRNA variants vs controls and across Gensini score severity
Design
Case-control study
Authors
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These lncRNA variants may link to CAD risk; leaves open clinical utility pending replication.
Case-Control (n=200)
No
Are angiogenesis-related lncRNA variants associated with CAD susceptibility and severity in patients undergoing angiography?
Specific variants in the MIAT and MALAT1 long non-coding RNAs are associated with angiographic CAD severity in an Egyptian cohort.
Elwazir et al. (2022) conducted a case-control in Coronary artery disease (n=200). Angiogenesis-related lncRNAs variants (PUNISHER, SENCR, MIAT, MALAT1, and GATA6-AS1) vs. Controls / Reference genotypes was evaluated on CAD susceptibility and severity (Gensini score). MIAT rs1061540 T/T genotype was associated with a more severe Gensini score, whereas MALAT1 rs3200401 T/C heterozygosity was associated with a lower score in patients with stable CAD.
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