Key result
The MALAT1 rs619586 G allele was significantly associated with a lower risk of congenital heart disease in a Chinese pediatric population (OR 0.77).
Why the study?
Does the MALAT1 gene polymorphism rs619586 affect the risk of congenital heart disease in Chinese children?
Population
1,443 Han Chinese children aged 1-60 months, including 713 patients with congenital heart disease diagnosed…
Comparison
Presence of MALAT1 tag-SNPs, specifically the… vs Wild-type/alternative alleles.
Design
Case-control
Authors
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Does not warrant changes in congenital heart disease risk assessment; leaves open the role of MALAT1 polymorphisms pending confirmatory studies.
Case-Control (n=1,443)
No
Does the MALAT1 gene polymorphism rs619586 affect the risk of congenital heart disease in Chinese children?
Odds Ratio: 0.77 (95% CI 0.59–0.92)
p-value: p=0.014
The MALAT1 rs619586 A>G polymorphism is significantly associated with a reduced susceptibility to congenital heart disease in a Chinese pediatric population, likely by upregulating MALAT1 expression.
Li et al. (2018) conducted a case-control in Congenital heart disease (n=1,443). MALAT1 rs619586 polymorphism (G allele) vs. A allele / non-carriers was evaluated on Risk of congenital heart disease (OR 0.77, 95% CI 0.59-0.92, p=0.014). The MALAT1 rs619586 G allele was significantly associated with a lower risk of congenital heart disease in a Chinese pediatric population (OR 0.77).
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