Why the study?
Abnormal expression and function of long non-coding RNAs relate to the pathogenesis of SLE, motivating an evaluation of whether MALAT-1 gene SNPs associate with SLE susceptibility and clinical characteristics.
Are MALAT-1 gene single-nucleotide polymorphisms associated with susceptibility to systemic lupus erythematosus?
Are MALAT-1 gene single-nucleotide polymorphisms associated with susceptibility to systemic lupus erythematosus?
The MALAT-1 rs4102217 polymorphism is associated with a decreased susceptibility to systemic lupus erythematosus.
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rs4102217 variant may inform SLE susceptibility research; leaves open causal role and clinical utility pending replication.
Mao et al. (2021) studied this question.
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