Key result
Bone marrow carcinomatosis from gastric adenocarcinoma presents as fatal TMA and DIC in a 19-year-old.
Why the study?
Carcinomatosis of the bone marrow accompanied by TMA and DIC is infrequent in patients with gastric carcinoma.
Case Report (n=1)
This case report highlights a rare and fatal presentation of thrombotic microangiopathy and disseminated intravascular coagulation secondary to bone marrow carcinomatosis from gastric adenocarcinoma in a young patient.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to bone marrow carcinomatosis in young gastric cancer with TMA/DIC; extends sparse case literature without guiding practice.
Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times. Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.
No takes yet. Share an insight, caveat, or question.
Suarez-Reyes et al. (2023) conducted a case report in Gastric adenocarcinoma with bone marrow carcinomatosis, thrombotic microangiopathy, and disseminated intravascular coagulation (n=1). Bone marrow carcinomatosis from gastric adenocarcinoma was evaluated on Clinical diagnosis and outcome. A 19-year-old female with gastric adenocarcinoma presented with a rare and fatal combination of thrombotic microangiopathy and disseminated intravascular coagulation due to bone marrow carcinomatosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: