Key result
VSARR in Marfan patients shows ~91% 10-year survival, higher than non-Marfan patients.
Why the study?
Does valve-sparing aortic root replacement (David I procedure) provide durable long-term outcomes in patients with Marfan disease compared to non-Marfan patients?
Population
582 patients who underwent valve-sparing aortic root replacement, including 104 patients with Marfan disease
Comparison
Valve-sparing aortic root replacement using the… vs Non-Marfan patients undergoing the same procedure
Design
Cohort
Follow-up
mean 12 ± 5.4 years
Authors
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Supports valve-sparing root replacement in Marfan patients; leaves open durability versus alternatives in randomized data.
Cohort (n=582)
No
Does valve-sparing aortic root replacement (David I procedure) provide durable long-term outcomes in patients with Marfan disease compared to non-Marfan patients?
p-value: p=<0.0001
The David I valve-sparing aortic root replacement procedure demonstrates excellent long-term durability and survival in Marfan patients over a 20-year period, with outcomes comparable or superior to non-Marfan patients.
Martens et al. (2018) conducted a cohort in Marfan disease with aortic root dilatation (n=582). Valve-sparing aortic root replacement (David I procedure) vs. Non-Marfan patients undergoing the same procedure was evaluated on Long-term survival at 10 years (p=<0.0001). Valve-sparing aortic root replacement in Marfan patients resulted in 91% survival at 10 years, which was significantly better than in non-Marfan patients (P<0.0001).
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