Key result
Phosphodiesterase inhibitors induce splanchnic and hindquarter vasodilation independent of beta-blockade in feline models.
Population
chloralosed cats (auto-perfused splanchnic region and hindquarters)
Design
Preclinical
Authors
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Does not support clinical use of PDE inhibitors for vasodilation; leaves open translation from feline models to humans.
Phosphodiesterase inhibitors induce vasodilation in the splanchnic and hindquarter vascular beds of cats, likely mediated by cyclic AMP accumulation in vascular smooth muscle.
Thomas C. Hamilton (1972) studied this question. Phosphodiesterase inhibitors was evaluated on Vascular conductance in the splanchnic region and hindquarters. Phosphodiesterase inhibitors acted as vasodilators in the splanchnic region and hindquarters of the cat, an effect not susceptible to beta-adrenoceptor blockade.
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