What does this research mean for the field?

Effusive-constrictive pericarditis occurs in over half of tuberculous pericardial effusion cases and is independently associated with pre-pericardiocentesis right atrial pressure greater than 15 mmHg and elevated IL-10 levels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 14, 2013PLoS ONEOpen Access

Right atrial pressure >15 mmHg linked to ~48-fold higher odds of effusive-constrictive tuberculous pericarditis.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Tuberculous pericardial effusion (n=68). Intervention: Right atrial pressure > 15 mmHg vs. Right atrial pressure ≤ 15 mmHg. Primary outcome: Effusive-constrictive pericarditis (ECP) (OR 48, 95% CI 8.7-265, p=<0.0001).

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Population

68 adults with tuberculous pericardial effusion (out of 91 evaluated patients)

Design

Cohort

Key result

Pre-pericardiocentesis right atrial pressure > 15 mmHg (OR 48) and serum IL-10 > 200 pg/ml (OR 10) were independently associated with effusive-constrictive pericarditis, which occurred in 52.9% of patients with tuberculous pericardial effusion.

Authors

MNMpiko Ntsekhe KMKerryn Matthews FSFaisal F. Syed

Discussion

Member takes

Overview

Effusive-constrictive pericarditis is highly prevalent (52.9%) in patients with tuberculous pericardial effusion and is characterized by elevated right atrial pressure and IL-10 levels.

Study Design

Type

Observational (n=68)

Multicenter

Structured PICO

Population

68 adults with probable or definite tuberculous pericardial effusion were prospectively evaluated to determine the prevalence and cytokine profile of effusive-constrictive pericarditis.

Comparator

Effusive non-constrictive tuberculous pericarditis

Outcome

Prevalence of effusive-constrictive pericarditis (ECP) and serum and pericardial levels of inflammatory cytokinessurrogate

Main Result

Odds Ratio: 48 (95% CI 8.7–265)

p-value: p=<0.0001

Effusive-constrictive pericarditis is highly prevalent (52.9%) in patients with tuberculous pericardial effusion and is characterized by elevated right atrial pressure and IL-10 levels.

Limitations

Selection bias due to enrolling only patients with moderate to large pericardial effusions amenable to safe pericardiocentesis.
Only 60% of cases had a proven diagnosis of tuberculosis, meaning the remaining 40% with a presumed diagnosis may have had other inflammatory causes.
Small sample size of 36 ECP cases limits the power of the study.

Cite This Study

Ntsekhe et al. (2013) conducted an observational in Tuberculous pericardial effusion (n=68). Right atrial pressure > 15 mmHg vs. Right atrial pressure ≤ 15 mmHg was evaluated on Effusive-constrictive pericarditis (ECP) (OR 48, 95% CI 8.7-265, p=<0.0001). Pre-pericardiocentesis right atrial pressure > 15 mmHg (OR 48) and serum IL-10 > 200 pg/ml (OR 10) were independently associated with effusive-constrictive pericarditis, which occurred in 52.9% of patients with tuberculous pericardial effusion.

synapsesocial.com/papers/6aa63f57b3a9aaf5308e427c https://doi.org/10.1371/journal.pone.0077532

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October 14, 2013PLoS ONEOpen Access

Right atrial pressure >15 mmHg linked to ~48-fold higher odds of effusive-constrictive tuberculous pericarditis.

View Full Paper

Ask AI

Bookmark

Population

68 adults with tuberculous pericardial effusion (out of 91 evaluated patients)

Design

Cohort

Key result

Authors

MNMpiko Ntsekhe KMKerryn Matthews FSFaisal F. Syed

Discussion

Member takes

Overview

Effusive-constrictive pericarditis is highly prevalent (52.9%) in patients with tuberculous pericardial effusion and is characterized by elevated right atrial pressure and IL-10 levels.

Study Design

Type

Observational (n=68)

Multicenter

Structured PICO

Population

68 adults with probable or definite tuberculous pericardial effusion were prospectively evaluated to determine the prevalence and cytokine profile of effusive-constrictive pericarditis.

Comparator

Effusive non-constrictive tuberculous pericarditis

Outcome

Prevalence of effusive-constrictive pericarditis (ECP) and serum and pericardial levels of inflammatory cytokinessurrogate

Main Result

Odds Ratio: 48 (95% CI 8.7–265)

p-value: p=<0.0001

Effusive-constrictive pericarditis is highly prevalent (52.9%) in patients with tuberculous pericardial effusion and is characterized by elevated right atrial pressure and IL-10 levels.

Limitations

Selection bias due to enrolling only patients with moderate to large pericardial effusions amenable to safe pericardiocentesis.
Only 60% of cases had a proven diagnosis of tuberculosis, meaning the remaining 40% with a presumed diagnosis may have had other inflammatory causes.
Small sample size of 36 ECP cases limits the power of the study.

Cite This Study

synapsesocial.com/papers/6aa63f57b3a9aaf5308e427c https://doi.org/10.1371/journal.pone.0077532

View Full Paper

Ask AI

Bookmark