Key result
Chemical ablation of olfactory sensory nerves greatly reduces cribriform CSF outflow without increasing intracranial pressure.
Why the study?
Does chemical ablation of olfactory sensory nerves reduce CSF outflow and alter intracranial pressure?
Population
Preclinical model studying cerebrospinal fluid (CSF) outflow along olfactory sensory nerves
Design
Preclinical
Authors
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Olfactory ablation reduces cribriform CSF outflow without ICP rise in animals; hypothesis-generating for CSF turnover in neurological disease.
Does chemical ablation of olfactory sensory nerves reduce CSF outflow and alter intracranial pressure?
Damage to olfactory sensory neurons reduces CSF outflow through the cribriform plate without increasing ICP, suggesting a potential mechanism for altered CSF turnover in neurological diseases.
S George (2004) studied CSF outflow physiology. Chemical ablation of olfactory sensory nerves was evaluated on Outflow of CSF through the cribriform plate and intracranial pressure. Chemical ablation of olfactory sensory nerves greatly reduced outflow of CSF through the cribriform plate without causing an increase in intracranial pressure.
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