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Saving solvent: An aqueous–ethyl acetate biphasic system allows an efficient synthesis of medium- and large-sized lactones by an intramolecular Tsuji–Trost reaction (see scheme, n=1–5). The macrocyclization protocol does not require a large quantity of solvents or a slow-addition technique.
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Kinoshita et al. (2005) studied this question.
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