Key result
Hemoglobin film biosensor enables quantitation of the anticancer drug adriamycin.
A hemoglobin-based electrochemical biosensor was successfully developed for the sensitive quantitation of the anticancer drug adriamycin.
Offers sensitive adriamycin quantitation for preclinical research; leaves open clinical translation without human validation studies.
Electrochemical biosensor is an effective tool for pharmaceutical analysis due to its simplicity, specificity, sensitivity, fast, cost effective and repetitive measurements with miniaturized and portable devices. The paper illustrates the detail methodology for development of an electrochemical biosensor based on hemoglobin (Hb) film modified for anticancer drug adriamycin (ADM). Square wave voltammetry (SWV) studies of the electrodes before and after immobilizing of HB shows the successful formation of a selectivity of the electrode. The proposed Hb based biosensor allows quantitation over the range 1 to 8010-8M, The suggested biosensor method can be successfully applied to the detection and determination of anticancer drug adriamycin in different drug formulations and can be suggested as a suitable sensor for analysis of Adriamycin in biological samples.ً.
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Al-Jawadi et al. (2019) studied this question. Electrochemical biosensor based on hemoglobin (Hb) film was evaluated on Quantitation of adriamycin. An electrochemical biosensor based on hemoglobin film allowed quantitation of the anticancer drug adriamycin over the range of 1 to 80x10^-8 M.
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