Key result
Altered lipids in ovarian cancer ascitic fluid are linked to T cell dysfunctionality.
Population
Ovarian cancer patients (ascites fluid) and normal abdominal fluid
Comparison
Analysis of 109 lipid mediators vs Normal abdominal fluid
Design
Preclinical
Authors
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Reversible T-cell dysfunction in ovarian ascites suggests microenvironmental inhibition; leaves open whether targeting acellular factors could restore antitumor immunity.
Observational
Lipid intermediates in the ascites of ovarian cancer patients may contribute to T cell dysfunction and facilitate tumor dissemination.
Wefers et al. (2018) conducted an observational in Ovarian cancer. Ascitic fluid vs. Normal abdominal fluid was evaluated on Differentially regulated lipids and T cell proliferation. Analysis of 109 lipid mediators showed differentially regulated lipids in the suppressive ascitic fluid of ovarian cancer patients compared to normal fluid, coinciding with T cell dysfunctionality.
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