Key result
Schizophrenia is linked to smaller biventricular volumes and greater LV concentricity and septal thickness.
Why the study?
Heart disease is the leading cause of death in schizophrenia, prompting investigation into cardiac structure and function using CMR after excluding medical and metabolic comorbidity.
Does schizophrenia associate with adverse cardiac remodeling compared to matched controls?
Case-Control (n=79)
Single-blind
Yes
Does schizophrenia associate with adverse cardiac remodeling compared to matched controls?
Patients with schizophrenia exhibit prognostically adverse cardiac remodeling independent of conventional risk factors, suggesting a potential intrinsic cardiac phenotype in this population.
Concentric remodelling on CMR in schizophrenia signals possible intrinsic cardiac risk; leaves open causality and need for prospective outcome studies.
Background Heart disease is the leading cause of death in schizophrenia. Aims We investigated cardiac structure and function in patients with schizophrenia using cardiac magnetic resonance imaging (CMR) after excluding medical and metabolic comorbidity. Methods 80 participants underwent CMR to determine biventricular volumes and function and measures of blood pressure, physical activity, and glycated haemoglobin levels. Patients and controls were matched for age, sex, ethnicity, and body surface area. Results Patients with schizophrenia had significantly smaller indexed left ventricular (LV) end-diastolic volume, end-systolic volume, stroke volume, right ventricular (RV) end-diastolic volume, end-systolic volume, and stroke volume but unaltered ejection fractions relative to controls. LV concentricity and septal thickness were significantly larger in schizophrenia. The findings were largely unchanged after adjusting for smoking or exercise levels and were independent of medication dose and duration. Conclusions Patients with schizophrenia show evidence of prognostically-adverse cardiac remodelling compared to matched controls, independent of conventional risk factors.
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Osimo et al. (2019) conducted a case-control in Schizophrenia (n=79). Schizophrenia vs. Healthy controls was evaluated on Indexed left ventricular end-diastolic volume (LVEDVi) (d=-0.82, p=0.001). Schizophrenia was associated with significantly smaller indexed biventricular volumes and greater left ventricular concentricity and septal thickness compared to healthy controls, independent of conventional risk factors.
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