Key result
AF is linked to higher circulating ICTP versus controls but unrelated to left atrial fibrosis.
Why the study?
Do peripheral levels of fibrosis biomarkers reflect intra-cardiac levels in patients undergoing catheter ablation for atrial fibrillation?
Population
129 patients, including 93 undergoing catheter ablation for paroxysmal atrial fibrillation or non-paroxysmal…
Comparison
Measurement of fibrosis biomarkers in femoral… vs Control patients and intra-patient comparison of…
Design
Cross-sectional
Authors
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Elevated peripheral ICTP in AF does not track left atrial voltage fibrosis; leaves open whether circulating biomarkers guide ablation decisions.
Observational (n=129)
Do peripheral levels of fibrosis biomarkers reflect intra-cardiac levels in patients undergoing catheter ablation for atrial fibrillation?
p-value: p=0.007
In patients undergoing AF ablation, peripheral sampling of FGF-23 and PIIINP reflects intra-cardiac levels, whereas intra-cardiac sampling may be necessary for gal-3 and ICTP, though none correlated with left atrial voltage fibrosis.
Begg et al. (2017) conducted an observational in Atrial fibrillation (n=129). Atrial fibrillation vs. Matched non-AF controls was evaluated on C-telopeptide of type I collagen (ICTP) levels (p=0.007). Atrial fibrillation patients had higher levels of circulating ICTP than matched non-AF controls (P=0.007), though none of the biomarkers related to fibrosis assessed by left atrial voltage.
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