Chiral 1,4‐benzodiazepines. XII. Conformation in a solution of 7‐chloro‐5‐phenyl‐3(S)methyl‐1,3‐dihydro‐2H‐1,4‐benzodiazepine

Deuterium labeled congeners of 7‐chloro‐5‐phenyl‐3(S)‐methyl‐1,3‐dihydro‐2H‐1,4‐benzodiazepine (8), i.e., compounds 9 and 16‐18 were prepared and their lis‐nmr spectra run. For computational studies compounds 9 and 16 were chosen. The results of lis measurements revealed that 16 is present in more than 97% in the boat‐like conformation I (Scheme 3).