An efficient synthesis of the 4H-quinolone alkaloid graveoline has been achieved by a route featuring an Pd(II)-catalysed reductive N-hetero-cyclisation [CO(3 MPa), Pd(TMB)2, TMPhen, 170°C, 3h] of 2′-nitrochalcone as a key step.
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Annunziata et al. (1996) studied this question.
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