Key result
Sodium azide and nitroprusside induce potent vasodilation and bronchodilation in guinea pigs, with hypotension predominating.
In guinea-pig models, the hypotensive effects of sodium azide and sodium nitroprusside predominate over their bronchodilator effects regardless of the route of administration.
Predominant hypotension may limit bronchodilator utility; animal data leaves open human translation.
Sodium azide and sodium nitroprusside are potent dilators of the intact guinea-pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea-pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea pig. 4. At all doses and by route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation.
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Jamieson et al. (1979) studied this question. Sodium azide and sodium nitroprusside was evaluated on Bronchodilator and vasodilator activity. Sodium azide and sodium nitroprusside act as potent bronchodilators and vasodilators in the guinea-pig, with the hypotensive effect predominating over bronchodilatation at all doses and routes.
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