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Eight cases of contact allergy to virginiamycin are reported. In all patients patch tests with fractions of both virginiamycin (factor M and S) and pristinamycin (fraction IA and IIA) were performed. All patients allergic to virginiamycin, reacted also to pristinamycin, factor M and fraction IIA. Chemically, factor M and fraction IIA appeared to be completely identical, implicating that we are dealing with false cross-sensitivity.
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H. Baes (2009) studied this question.
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