Key result
Diabetes or IFG is linked to markedly lower TCRT values versus controls.
Why the study?
Despite an increased risk for arrhythmias, little is known about cardiac repolarization abnormalities in patients with diabetes mellitus and no known cardiac disease.
Does diabetes mellitus or impaired fasting glucose associate with abnormal T-wave morphology markers in patients without overt cardiac disease?
Case-Control (n=124)
Does diabetes mellitus or impaired fasting glucose associate with abnormal T-wave morphology markers in patients without overt cardiac disease?
Absolute Event Rate: 0.06% vs 0.43%
p-value: p=<0.01
Patients with diabetes or impaired fasting glucose without overt cardiac disease exhibit reduced total cosine R to T (TCRT), indicating early subclinical abnormalities in cardiac repolarization.
Abnormal T-wave markers may signal repolarization issues in DM without overt disease; leaves open prognostic value for arrhythmia risk.
Patients with diabetes mellitus (DM) are prone to advanced atherosclerosis, microvascular disease, and tissue fibrosis. Despite the increased risk for arrhythmias, little is known about cardiac repolarization abnormalities in DM. We aimed to determine whether abnormal T-wave morphology markers are common among patients with DM and no known cardiac disease. Patients were recruited and classified as having DM or impaired fasting glucose (IFG) according to accepted guidelines. Total cosine R to T (TCRT) and T-wave morphology dispersion (TMD) were computed with custom-designed software for randomly selected and averaged beats. Among 124 patients recruited; 47 were diagnosed with DM and 3 IFG. DM patients and the control group had similar clinical characteristics, other than statins and anti-diabetic drugs, which were more common among DM patients. Patients with DM/IFG had decreased TCRT values computed from a random beat (0.06 ± 0.10 vs. 0.43 ± 0.07, p < 0.01) and an average beat (0.08 ± 0.09 vs. 0.44 ± 0.06, p < 0.01), when compared with the control group. TMD parameters did not differ. In conclusion, TCRT is reduced in patients with DM and no known cardiac diseases. Further research is required to investigate whether repolarization-associated changes in DM are the consequence of subclinical atherosclerosis, diabetic cardiomyopathy, or a combination of the two.
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Stahi et al. (2022) conducted a case-control in Diabetes mellitus without overt cardiac disease (n=124). Diabetes mellitus or impaired fasting glucose vs. Control group was evaluated on Total cosine R to T (TCRT) computed from a random beat (p=<0.01). Diabetes mellitus or impaired fasting glucose was associated with significantly decreased TCRT values compared to controls (0.06 vs. 0.43, p < 0.01).
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