Laboratory investigation reveals negligible autoregulation of Lac repressor expression in Escherichia coli, indicating that negative feedback via the O3 operator is biologically insignificant.
Negative feedback regulation, mediated through repressor binding site O3, which overlaps the lacI gene, could explain the robustness of the weak expression of Lac repressor. Significant autorepression of Lac repressor has never been ruled out. In the work presented here, the degree of autoregulation of Lac repressor was determined. It is negligible.
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Stefan Oehler (2009) studied this question.
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