Impact of heart rate and PR interval on Doppler indexes of left ventricular diastolic filling in an elderly cohort (the Framingham Heart Study)
Key result
Heart rate and PR interval independently associate with LV diastolic filling in the elderly.
- P<0.01
- n=722
Why the study?
Do heart rate and PR interval affect Doppler indexes of left ventricular diastolic filling in an elderly cohort?
Population
722 subjects from the Framingham Heart Study. Excluded: subjects receiving antihypertensive or cardiac…
Design
Cross-sectional
Authors
Discussion
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Implication
May support accounting for heart rate and PR interval in diastolic assessment; hypothesis-generating for causality and outcomes.
Study Design
Type
Cohort (n=722)
Structured PICO
Do heart rate and PR interval affect Doppler indexes of left ventricular diastolic filling in an elderly cohort?
P
Population
722 elderly adults (mean age 75.6 years) from the Framingham Heart Study, free of cardiac medications and major cardiovascular diseases.
O
Outcome
Doppler-derived diastolic indexes (Peak velocity of early (E) and late (A) diastolic left ventricular filling, ratio of peak velocities E/A, ratio of time velocity integrals E/A, and atrial filling fraction)surrogate
Main Result
p-value: p=<0.01
Heart rate and PR interval are independent determinants of Doppler-assessed LV diastolic filling in the elderly, highlighting the need to account for these variables during echocardiographic assessment.
Cite This Study
Galderisi et al. (1993) conducted a cohort in Elderly (n=722). Heart rate and PR interval was evaluated on Doppler indexes of left ventricular diastolic filling (peak velocity E and A, E/A ratio, time velocity integral E/A, and atrial filling fraction) (p=<0.01). Heart rate and PR interval independently determine Doppler-assessed left ventricular diastolic filling in the elderly, with PR interval inversely associated with time velocity integral E/A (p<0.01).