Key result
Higher CRP-to-albumin ratio predicts postoperative delirium after TAVR.
Why the study?
The study investigated whether C-reactive protein-to-albumin ratio predicts postoperative delirium development in patients undergoing transcatheter aortic valve replacement.
Does the C-reactive protein-to-albumin ratio predict postoperative delirium in patients undergoing transcatheter aortic valve replacement?
Observational (n=78)
Does the C-reactive protein-to-albumin ratio predict postoperative delirium in patients undergoing transcatheter aortic valve replacement?
The C-reactive protein-to-albumin ratio is a promising independent predictor of postoperative delirium in patients undergoing TAVR.
Answers are grounded in this paper and cite their sources.
CAR may aid delirium risk stratification after TAVR; hypothesis-generating and requires prospective validation.
Transkateter Aort Kapak Replasmanı Uygulanan Hastalarda Postoperatif Deliryum İçin Yeni Bir Enflamatuvar Biyobelirteç Olarak C-reaktif Protein/Albümin OranıAim: We aimed to investigate whether C-reactive protein-toalbumin ratio (CAR) predicts postoperative delirium (POD) development in patients undergoing transcatheter aortic valve replacement (TAVR) procedure.Methods: Data of 78 patients with the mean age of 76.3±8.4 years, who underwent TAVR, were retrospectively analyzed.The CAR, neurophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio values were calculated in all patients.Presence of delirium was determined by using the Richmond Agitation-sedation scale and the Confusion Assessment Method for the Intensive Care Unit.Results: As compared with the nondelirious group, delirious patients had significantly higher EuroSCORE II (p=0.03) and TAVR score (p=0.009) and more frequent major bleeding (p=0.005),major vascular complications (p=0.018) and acute kidney injury (AKI) (p=0.002).The main independent predictors of POD were CAR value (p=0.02),AKI (p=0.02),major bleeding (p=0.005), and TAVR score (p=0.04).The area under the curve of CAR for POD development was 0.718 (95% confidence interval: 0.605-0.814;p=0.002) with 82% sensitivity and 56% specificity.Conclusion: CAR is a promising inflammatory parameter in predicting POD and may help identify subgroups of individuals at risk for POD.
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Kalyoncuoğlu et al. (2020) conducted an observational in Postoperative delirium in patients undergoing transcatheter aortic valve replacement (n=78). C-reactive protein-to-albumin ratio (CAR) was evaluated on Postoperative delirium (POD) development (AUC 0.718, 95% CI 0.605-0.814, p=0.002). C-reactive protein-to-albumin ratio predicted postoperative delirium in patients undergoing TAVR (AUC 0.718; 95% CI 0.605-0.814; p=0.002).
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