Key result
Retroperitoneal myxoid liposarcoma dedifferentiates into high-grade disease, leading to death after ~14 years.
Case Report (n=1)
Repeated resections of retroperitoneal liposarcoma can lead to dedifferentiation into a highly malignant form, necessitating strict follow-up.
May warrant close surveillance after repeated resections for retroperitoneal liposarcoma; leaves open prospective validation of risk and strategies.
症例は69歳の女性．平成５年２月より後腹膜原発脂肪肉腫に対して４回の腫瘤摘出術が施行されていたが，平成18年１月に再発に対して５回目の手術を行った．組織学的に粘液型が主体であったが，５回目の切除標本では脱分化型へと移行していた．３カ月後に６回目の摘出術が施行されたが，その２カ月後にはすでに再発が認められ，化学療法を施行したが効果なく，初回手術から13年９カ月後に永眠された．後腹膜脂肪肉腫は，surgical marginを確保した切除を行うことで長期予後も期待できるが，再発に伴う複数回の切除で悪性度の高い脱分化型が出現することがあり，厳重な経過観察が必要である．
No takes yet. Share an insight, caveat, or question.
Hai et al. (2012) conducted a case report in Retroperitoneal liposarcoma (n=1). Surgical resection was evaluated. A retroperitoneal liposarcoma initially diagnosed as myxoid type dedifferentiated into a high-grade dedifferentiated type over the course of 6 surgical resections, leading to death after 13.75 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: