Key result
Extracellular vesicles from hypoxic adipocytes and obese subjects significantly decreased insulin-stimulated 2-deoxyglucose uptake in cultured adipocytes (p=0.0159).
p-value: p=0.0159
Extracellular vesicles released by stressed adipocytes or from obese subjects impair insulin action and glucose uptake in neighboring adipocytes, suggesting a mechanism for insulin resistance.
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Adipocyte-derived EVs may impair local insulin action in obesity; hypothesis-generating for their systemic metabolic role.
Mleczko et al. (2018) studied Obesity. Extracellular vesicles from hypoxic adipocytes and obese subjects vs. Extracellular vesicles from normoxic adipocytes and lean individuals was evaluated on Insulin-stimulated 2-deoxyglucose uptake (p=0.0159). Extracellular vesicles from hypoxic adipocytes and obese subjects significantly decreased insulin-stimulated 2-deoxyglucose uptake in cultured adipocytes (p=0.0159).
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