Key result
Diabetes linked to ~1.8-fold higher plasma Urotensin II levels versus healthy subjects.
Why the study?
Are plasma Urotensin II levels elevated in diabetic patients with normal renal function compared to healthy subjects?
Population
Diabetic patients with normal serum creatinine levels, healthy subjects, and cultured human coronary artery…
Design
Cross-sectional
Authors
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Elevated Urotensin II in normoproteinuric diabetes may signal early risk; hypothesis-generating and requires prospective validation before clinical use.
Observational
Are plasma Urotensin II levels elevated in diabetic patients with normal renal function compared to healthy subjects?
Effect estimate: 1.8-fold
Absolute Event Rate: 7.8% vs 4.4%
p-value: p=<0.0001
Plasma Urotensin II levels are elevated in diabetic patients without renal failure, suggesting a potential role in diabetic cardiovascular and organ complications.
Totsune et al. (2003) conducted an observational in Diabetes mellitus. Diabetes mellitus vs. Healthy subjects was evaluated on Plasma Urotensin II levels (1.8-fold, p=<0.0001). Plasma Urotensin II levels were significantly elevated in diabetic patients without (7.8 fmol/ml; P<0.0001) and with proteinuria (7.3 fmol/ml; P=0.0018) compared to healthy subjects (4.4 fmol/ml).
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